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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.

To eat or to sleep? Orexin in the regulation of feeding and wakefulness.

Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

Orexin (hypocretin) neurons contain dynorphin.

Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.



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